（1）利用既往数据，建立北大通州回顾性队列
基于通州区妇幼保健院电子信息系统导出数据，经过为时数月的数据清理、现场调研和讨论分析，形成了覆盖2013-2020年该院妇幼保健数据资料、并可直接用于统计分析的数据库，数据库由专人管理。截止2023年6月，利用回顾性队列数据，项目组已在产前保健、孕期保健、胎儿生长发育、妊娠结局、儿童保健和妇女保健研究方向取得进展，共发表或接收23篇中文核心期刊文章及21篇SCI文章。
（2）基于国家级项目，建立北大通州出生队列
2018年，在国家自然科学基金项目和北京大学医学部“双一流”建设经费的支持下，在通州妇幼保健院建立北大通州出生队列，以探讨孕期各项因素对母婴健康的影响，为高危因素的识别和疾病预防控制提供高质量证据，从而促进母婴安全及健康。当前，队列已入组5426名孕妇，收集问卷1.4万余份、孕早期和孕中期血清等生物样本共10万余份、胎盘组织生物样本共1千余份、脐带血生物样本共1.4千余份。基于该队列，妇幼系及通州妇幼保健院合作申请课题获2019年国家自然科学基金项目资助。截至2023年6月，已在妊娠期糖尿病、孕期睡眠障碍、孕期营养和孕期抑郁研究方向已接收或发表11篇SCI文章和3篇中文文章。
[1] Jin C, Lin L, Han N, et al. Effects of dynamic change in fetuin-A levels from the first to the second trimester on insulin resistance and gestational diabetes mellitus: a nested case-control study[J]. BMJ Open Diabetes Res Care. 2020;8(1):e000802.
[2] Jin C, Lin L, Han N, et al. Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study[J]. Nutr Metab (Lond). 2020;17:1.
[3] Jin C, Lin L, Han N, et al. Risk of Gestational Diabetes Mellitus in relation to Plasma Concentrations of Fatty Acid-Binding Protein 4: A Nested Case-Control Study in China[J]. J Diabetes Res. 2021 Jul 28;2021:6681432.
[4] Xu X, Wang Y, Han N, et al. Early Pregnancy Exposure to Rare Earth Elements and Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study[J]. Front Endocrinol (Lausanne). 2021 Dec 20;12:774142.
[5] Du M, Liu J, Han N, et al. Association between sleep duration in early pregnancy and risk of gestational diabetes mellitus: a prospective cohort study[J]. Diabetes Metab. 2020 Dec 16;47(5):101217.
[6] Du M, Liu J, Han N, et al. Maternal sleep quality during early pregnancy, risk factors and its impact on pregnancy outcomes: a prospective cohort study[J]. Sleep Med. 2021 Mar;79:11-18.
[7] Du M, Liu J, Han N, et al. Exploring the mediating role of serum retinol-binding protein 4 in the relationship between sleep quality and insulin resistance in pregnant women[J]. Diabetes Res Clin Pract. 2021 Jun;176:108866.
[8] Yang W, Han N, Jiao M, et al. Maternal diet quality during pregnancy and its influence on low birth weight and small for gestational age: a birth cohort in Beijing, China [published online ahead of print, 2022 Mar 7]. Br J Nutr. 2022;1-10. doi:10.1017/S0007114522000708.
[9] Zhou S, Li T, Han N, et al. The associations of prenatal exposure to PM2.5 and its constituents with fetal growth: A prospective birth cohort in Beijing, China. Environ Res. 2022;214(Pt 4):114196. doi:10.1016/j.envres.2022.114196.
[10] Zhou S, Guo Y, Su T, et al. Individual and joint effect of indoor air pollution index and ambient particulate matter on fetal growth: a prospective cohort study. Int J Epidemiol. 2023;52(3):690-702. doi:10.1093/ije/dyad021.
[11] Liu Z, Han N, Su T, et al. Interpretable machine learning to identify important predictors of birth weight: A prospective cohort study. Front Pediatr. 2022;10:899954. Published 2022 Nov 11. doi:10.3389/fped.2022.899954.
[12] Jin C, Lin L, Han N, et al. Excessive gestational weight gain and the risk of gestational diabetes: Comparison of Intergrowth-21st standards, IOM recommendations and a local reference[J]. Diabetes Res Clin Pract. 2019;158:107912.
[13] Peng Y, Han N, Su T, et al. Gestational weight gain and the risk of gestational diabetes mellitus: A latent class trajectory analysis using birth cohort data[J]. Diabetes Res Clin Pract. 2021 Dec;182:109130.
[14] Lyu J, Sun Y, Ji Y, et al. Optimal Gestational Weight Gain for Women with Gestational Diabetes Mellitus - China, 2011-2021. China CDC Wkly. 2023;5(9):189-193. doi:10.46234/ccdcw2023.034.
[15] Jin D, Rich-Edwards JW, Chen C, et al. Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22-24 Weeks: A Retrospective Cohort Study of Medical Records[J]. Nutrients. 2020 Nov 27;12(12):3645.
[16] Yuan Z, Wang HJ, Su T, et al. The First-Trimester Gestational Weight Gain Associated With de novo Hypertensive Disorders During Pregnancy: Mediated by Mean Arterial Pressure[J]. Front Nutr. 2022 Apr 13;9:862323.
[17] Tang Z, Ji Y, Zhou S, et al. Development and Validation of Multi-Stage Prediction Models for Pre-eclampsia: A Retrospective Cohort Study on Chinese Women. Front Public Health. 2022;10:911975. Published 2022 May 30. doi:10.3389/fpubh.2022.911975.
[18] Chen J, Ji Y, Su T, et al. Prediction of Adverse Outcomes in De Novo Hypertensive Disorders of Pregnancy: Development and Validation of Maternal and Neonatal Prognostic Models. Healthcare (Basel). 2022;10(11):2307. Published 2022 Nov 18. doi:10.3390/healthcare10112307.
[19] Yuan Z, Li Q, Su T, et al. Effects of fine ambient particulate matters on de novo hypertensive disorders of pregnancy and blood pressure before 20 weeks. Environ Res. 2023;218:115023. doi:10.1016/j.envres.2022.115023.
[20] Yuan Z, Wang HJ, Li Q, et al. Risk of De Novo Hypertensive Disorders of Pregnancy After Exposure to PM1 and PM2.5 During the Period From Preconception to Delivery: Birth Cohort Study. JMIR Public Health Surveill. 2023;9:e41442. Published 2023 Jan 23. doi:10.2196/41442.
[21] Yan S, Lyu J, Liu Z, Zhou S, Ji Y, Wang H. Association of gestational hypertension and preeclampsia with offspring adiposity: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2022;13:906781. Published 2022 Aug 23. doi:10.3389/fendo.2022.906781.
[22] Yang W, Jiao M, Xi L, et al. The association between maternal fat-soluble vitamin concentrations during pregnancy and infant birth weight in China[J]. Br J Nutr. 2021 May 14;125(9):1058-1066.
[23] Zhou Q, Jiao M, Han N, et al. The Influence of Maternal Vitamin E Concentrations in Different Trimesters on Gestational Diabetes and Large-for-Gestational-Age: A Retrospective Study in China[J]. Nutrients. 2022 Apr 14;14(8):1629.
[24] Wang H, Wang HJ, Jiao M, et al. Associations between Dynamic Vitamin D Level and Thyroid Function during Pregnancy. Nutrients. 2022;14(18):3780. Published 2022 Sep 14. doi:10.3390/nu14183780.
[25] Ji Y, Xu J, Su T, et al. Effect of levothyroxine treatment on fetal growth among women with mild subclinical hypothyroidism and thyroid peroxidase antibody negative: a cohort study. BMC Pregnancy Childbirth. 2023;23(1):362. Published 2023 May 18. doi:10.1186/s12884-023-05676-5.
[26] Liu Z, Liu H, Xu X, et al. Combined Effect of Maternal Vitamin D Deficiency and Gestational Diabetes Mellitus on Trajectories of Ultrasound-Measured Fetal Growth: A Birth Cohort Study in Beijing, China[J]. J Diabetes Res. 2020;2020:4231892.
[27] Lin L, Li Q, Yang J, et al. The associations of particulate matters with fetal growth in utero and birth weight: A birth cohort study in Beijing, China[J]. Sci Total Environ. 2020;709:136246.
[28] Lin L, Li Q, Yang J, et al. The associations of residential greenness with fetal growth in utero and birth weight: A birth cohort study in Beijing, ChinaJ[J]. Environ Int. 2020;141:105793.
[29] Lin L, Guo Y, Han N, et al. Prenatal exposure to airborne particulate matter of 1 μm or less and fetal growth: A birth cohort study in Beijing, China[J]. Environ Res. 2021 Mar;194:110729.
[30] Zhou S, Lin L, Bao Z, et al. The association of prenatal exposure to particulate matter with infant growth: A birth cohort study in Beijing, China[J]. Environ Pollut. 2021 May 15;277:116792.
[31] Zhou S, Guo Y, Bao Z, et al. Individual and joint effects of prenatal green spaces, PM2.5 and PM1 exposure on BMI Z-score of children aged two years: A birth cohort study[J]. Environ Res. 2022 Apr 1;205:112548.
[32] Wang S, Li L, Yang J, et al. Comparison of Different HPV-based Strategies and Cytology in Routine Cervical Cancer Screening Programme in China: A Population-based Study[J]. Cancer Prev Res (Phila). 2022;15(1):45-54.
