1. 本队列已纳入调查对象2万多个家庭。构建了涵盖母系、父系和子代的健康信息数据库，采集了包含血液、胎盘、口咽分泌物、尿液、粪便等生物样本共计近十万份，并构建了具有20台超低温冰箱的壮族人群生物标本库。

2. 本队列首次绘制了基于出生队列的壮族人群母婴疾病谱，创新性建立多个不良出生结局发生风险预测模型，为壮民族地区孕产期应重点防制的母婴疾病提供了重要依据；发现孕期多种环境内分泌干扰物暴露对母体健康及胎儿生长发育、出生结局的不良影响，为妇幼卫生部门精准制定相关预防控制措施提供了重要依据；筛选出多种先天性心脏病的生物标志物，促进了疾病早期发现和诊断。

3. 累计已发表学术论文70多篇，其中SCI论文20多篇，中文核心期刊40多篇，获专利1项。培养青年教师和研究生上百人，团队成员在此期间获国家自然基金19项。

4. 本队列研究成果“壮族人群出生队列研究平台的构建与应用”获2023年广西科技进步一等奖。

[1] Qian Liao, Huishen Huang, Peng Tang, Jun Liang, Jiehua Chen, Lei Lei, Yanye Song, Dongxiang Pan, Mengrui Lin, Fangfang Lv, Xue Liang, Xiaoyun Zeng, Shun Liu*, Dongping Huang* & Xiaoqiang Qiu*.Association Between Prenatal Per- and Polyfluoroalkyl Substance Exposure and Maternal Serum Total Bile Acid Levels During Pregnancy: Effect Modification by Infant Sex and Maternal Prepregnancy BMI.Exposure and Health.2023 Jul 27. doi: 10.1007/s12403-023-00588-3

[2] Jinxiu Li#, Dongping Huang#, Jun Liang, Jiehua Chen, Lei Lei, Mengrui Lin, Kaili Wu, Suyang Xiao, Mingshuang Lai, Xiaoqiang Qiu, Zhengmin Min Qian, Michael G Vaughn, Stephen Edward McMillin, GuangHui Dong, Xiaoyun Zeng*, Shun Liu*. Physical activity during pregnancy and adverse birth outcome: a prospective cohort study in China. J Matern Fetal Neonatal Med. 2022 Dec;2023,36(1):2162819. doi: 10.1080/14767058.2022.2162819.

[3] Chen C, Song Y, Tang P, Pan D, Wei B, Liang J, Sheng Y, Liao Q, Huang D*, Liu S*, Qiu X*. Association between prenatal exposure to perfluoroalkyl substance mixtures and intrauterine growth restriction risk: A large, nested case-control study in Guangxi, China. Ecotoxicol Environ Saf. 2023 Jul 5;262:115209. doi: 10.1016/j.ecoenv.2023.115209. Epub ahead of print. PMID: 37418866.

[4] Pan D, Lin M, Mu C, Yu C, Ye B, Liang J, Sheng Y, Huang D, Liu S, Zeng X, Jennifer Tan HJ, Chongsuvivatwong V*, Qiu X*. Maternal exposure to neonicotinoid insecticides and fetal growth restriction: A nested case-control study in the guangxi Zhuang birth cohort. Chemosphere. 2023 Sep;336:139217. doi: 10.1016/j.chemosphere.2023.139217. Epub 2023 Jun 17. PMID: 37336441.

[5] Liao Q, Tang P, Fan H, Song Y, Liang J, Huang H, Pan D, Mo M, LeiLei, Lin M, Chen J, Wei H, Long J, Shao Y, Zeng X, Liu S, Huang D, Qiu X*. Association between maternal exposure to per- and polyfluoroalkyl substances and serum markers of liver function during pregnancy in China: A mixture-based approach. Environ Pollut. 2023 Apr 15;323:121348. doi: 10.1016/j.envpol.2023.121348. Epub 2023 Feb 24. PMID: 36842621.

[6] Tang P, He W, Shao Y, Liu B, Huang H, Liang J, Liao Q, Tang Y, Mo M, Zhou Y, Li H, Huang D, Liu S, Zeng X, Qiu X*. Associations between prenatal multiple plasma metal exposure and newborn telomere length: Effect modification by maternal age and infant sex. Environ Pollut. 2022 Oct 18:120451. doi: 10.1016/j.envpol.2022.120451. Epub ahead of print. PMID: 36270567.

[7] Chen Jiehua#, Ye Y#, Huang D, Pan D, Qiu X, Lei L, Luo X, Li J, Wu K, Xiao S, Liu S*, Zeng Xiaoyun*. The mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi, China. Environ Sci Pollut Res Int. 2022 Jan 23. doi: 10.1007/s11356-021-18186-8

[8] Lei Lei#, Shun Liu#, Ye Ye, Xiaoqiang Qiu, Dongping Huang, Dongxiang Pan, Jiehua Chen, Zhengmin Qian, Stephen Edward McMillin, Michael Gc. Vaughn, Xingxi Luo, Kaili Wu, Suyang Xiao, Jinxiu Li, Meiliang Liu, Yu Yang, Mingshuang Lai, Guanghui Dong*, Xiaoyun Zeng*. Associations between serum aflatoxin-B1 and anemia in pregnant women: Evidence from Guangxi Zhuang Birth Cohort in China. Toxins. 2021 Nov 15;13(11):806. doi: 10.3390/toxins13110806.

[9] Liao Q, Tang P, Pan D, Song Y, Lei L, Liang J, Liu B, Lin M, Huang H, Mo M, Huang C, Wei M, Liu S*, Huang D*, Qiu X*. Association of serum per- and polyfluoroalkyl substances and gestational anemia during different trimesters in Zhuang ethnic pregnancy women of Guangxi, China. Chemosphere. 2022 Dec;309(Pt 2):136798. doi: 10.1016/j.chemosphere.2022.136798. Epub 2022 Oct 8. PMID: 36220436.

[10] Liao Q, Tang P, Song Y, Liu B, Huang H, Liang J, Lin M, Shao Y, Liu S, Pan D*, Huang D*, Qiu X*. Association of single and multiple prefluoroalkyl substances exposure with preterm birth: Results from a Chinese birth cohort study. Chemosphere. 2022 Nov;307(Pt 1):135741. doi: 10.1016/j.chemosphere.2022.135741. Epub 2022 Jul 18. PMID: 35863418.

[11] Huang H, Liang J, Tang P, Yu C, Fan H, Liao Q, Long J, Pan D, Zeng X, Liu S, Huang D, Qiu X. Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China. Environ Sci Pollut Res Int. 2022 Dec;29(58):87170-87183. doi: 10.1007/s11356-022-21817-3. Epub 2022 Jul 8. PMID: 35802331.

[12] Chen C, Tang P, Liang J, Huang D, Pan D, Lin M, Wu L, Wei H, Huang H, Sheng Y, Song Y, Wei B, Liao Q, Liu S, Qiu X*. Association between Intrauterine Microbiome and Risk of Intrauterine Growth Restriction: A Case-Control Study Based on Guangxi Zhuang Birth Cohort in China. Tohoku J Exp Med. 2022 Aug 4;258(1):11-21. doi: 10.1620/tjem.2022.J033. Epub 2022 Apr 28. PMID: 35491121.

[13] Guo X, Sheng Y, Liu B, Tang P, Liu R, Wu L, Chen J, Huang D, Liu S, Qiu X*. Exposure to phthalates in early pregnancy and the risk of fetal growth restriction: a nested case-control study in a Zhuang Chinese population. Environ Sci Pollut Res Int. 2022 Aug;29(38):57318-57329. doi: 10.1007/s11356-022-19919-z. Epub 2022 Mar 29. PMID: 35352222.

[14] Pan D, Shao Y, Song Y, Huang D, Liu S, Zeng X, Liang J, Juan Jennifer Tan H, Qiu X*. Association between maternal per- and polyfluoroalkyl substance exposure and newborn telomere length: Effect modification by birth seasons. Environ Int. 2022 Mar;161:107125. doi: 10.1016/j.envint.2022.107125. Epub 2022 Feb 17. PMID: 35183942.

[15] Pan D, Liu S, Huang D, Zeng X, Zhang Y, Pang Q, Wu H, Tan HJJ, Liang J, Sheng Y, Qiu X*. Effects of household environmental exposure and ventilation in association with adverse birth outcomes: A prospective cohort study in rural China. Sci Total Environ. 2022 May 20;822:153519. doi: 10.1016/j.scitotenv.2022.153519. Epub 2022 Jan 29. PMID: 35101501.

[16] Liang J#, Yang C#, Liu T, Tang P, Huang H, Wei H, Liao Q, Long J, Zeng X, Liu S, Huang D, Qiu X*. Single and mixed effects of prenatal exposure to multiple bisphenols on hemoglobin levels and the risk of anemia in pregnant women. Environ Res. 2022 May 1;207:112625. doi: 10.1016/j.envres.2021.112625. Epub 2021 Dec 30. PMID: 34973942.

[17] Tang P#, Liang J#, Liao Q, Huang H, Guo X, Lin M, Liu B, Wei B, Zeng X, Liu S*, Huang D*, Qiu X*. Associations of bisphenol exposure with the risk of gestational diabetes mellitus: a nested case-control study in Guangxi, China. Environ Sci Pollut Res Int. 2021 Nov 27. doi: 10.1007/s11356-021-17794-8. Epub ahead of print. PMID: 34837624.

[18] Liang J#, Yang C#, Liu T, Tan HJJ, Sheng Y, Wei L, Tang P, Huang H, Zeng X, Liu S*, Huang D*, Qiu X*. Prenatal exposure to bisphenols and risk of preterm birth: Findings from Guangxi Zhuang birth cohort in China. Ecotoxicol Environ Saf. 2021 Nov 12;228:112960. doi: 10.1016/j.ecoenv.2021.112960. Epub ahead of print. PMID: 34781130.

[19] Liu B#, Wei B#, Mo M, Song Y, Tang C, Tang P, Guo X, Tan C, Liu S*, Huang D*, Qiu X*. Exposure to perfluoroalkyl substances in early pregnancy and the risk of hypertensive disorders of pregnancy: A nested case-control study in Guangxi, China. Chemosphere. 2022 Feb;288(Pt 1):132468. doi: 10.1016/j.chemosphere.2021.132468. Epub 2021 Oct 5. PMID: 34624345.

[20] Liang J#, Shao Y#, Huang D#, Yang C, Liu T, Zeng X, Li C, Tang Z, Juan JTH, Song Y, Liu S*, Qiu X*. Effects of prenatal exposure to bisphenols on newborn leucocyte telomere length: a prospective birth cohort study in China. Environ Sci Pollut Res Int. 2021 May 24. doi: 10.1007/s11356-021-14496-z. Epub ahead of print. PMID: 34031828. 

[21] Feng B#, Li H#, Peng Y, Jiang Q, Wu Y, Liu S, Zeng X, Qiu X*, Huang D*. A cohort study of dysmenorrhea and risk of low birth weight. J Matern Fetal Neonatal Med. 2021 Apr 25:1-7. doi: 10.1080/14767058.2021.1914581. Epub ahead of print. PMID: 33899665. 

[22] Wei B, Shao Y, Liang J, Tang P, Mo M, Liu B, Huang H, Tan HJJ, Huang D*, Liu S*, Qiu X*. Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China. BMC Pregnancy Childbirth. 2021 Apr 9;21(1):283. doi: 10.1186/s12884-021-03757-x. PMID: 33836691; PMCID: PMC8033662. 

[23] Liang J, Liu S, Liu T, Yang C, Wu Y, Jennifer Tan HJ, Wei B, Ma X, Feng B, Jiang Q, Huang D*, Qiu X*. Association of prenatal exposure to bisphenols and birth size in Zhuang ethnic newborns. Chemosphere. 2020 Aug;252:126422. doi: 10.1016/j.chemosphere.2020.126422. Epub 2020 Mar 4. PMID: 32199162. 

[24] Sheng Y, Huang D, Liu S, Guo X, Chen J, Shao Y, Zhang G, Wei L, Zeng X, Qiu X*. Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women. Biomed Res Int. 2018 Nov 14;2018:2032413. doi: 10.1155/2018/2032413. PMID: 30539005; PMCID: PMC6261080.

[25] Zhao R, Wu Y, Zhao F, Lv Y, Huang D, Wei J, Ruan C, Huang M, Deng J, Huang D*, Qiu X*. The risk of missed abortion associated with the levels of tobacco, heavy metals and phthalate in hair of pregnant woman: A case control study in Chinese women. Medicine (Baltimore). 2017 Dec;96(51):e9388. doi: 10.1097/MD.0000000000009388. PMID: 29390543; PMCID: PMC5758245.

[26] Long J, Liu S, Zeng X, Yang X, Huang H, Zhang Y, Chen J, Xu Y, Huang D*, Qiu X*. Population Study Confirms Serum Proteins' Change and Reveals Diagnostic Values in Congenital Ventricular Septal Defect. Pediatr Cardiol. 2017 Aug;38(6):1191-1197. doi: 10.1007/s00246-017-1641-6. Epub 2017 May 29. PMID: 28553678.

[27] 廖倩,梁军,黄东萍,刘顺,郭晓婧,仇小强*.孕妇分娩年龄和初潮年龄间隔年数与大于胎龄儿的相关性[J].中华疾病控制杂志,2022,26(03):297-301.DOI:10.16462/ j.cnki.zhjbkz. 2022. 03.010

[28] 黄荟深,廖倩,唐鹏,梁军,范皓然,龙静铧,陈谦,刘顺,黄东萍,仇小强*.孕妇孕早期血浆钼浓度与新生儿出生体重和身长的相关性[J].广西医科大学学报,2022,39(06):963-969. DOI: 10.16190/ j.cnki.45-1211/r.2022.06.022

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[31] 伍柳玉#，兰景尤，黄丹丹，仇小强，刘美良，梁秋丽，张迪，曾小云*.基于产检信息的Bayes判别分析在巨大儿发生风险中的初步探讨.中华疾病控制杂志,2019 , 23(11):1338 -1341

[32] 秦小玲#，刘顺，郭雪峰，王能，仇小强，庞婷，李柯桦，刘美良，伍柳玉，曾小云*.南宁市武鸣区壮族人群小于胎龄儿的影响因素研究. 中华疾病控制杂志,2019 , 23( 1): 24-28

[33] 韦良家,刘顺,黄东萍,郭雪峰,盛勇红,莫美乐,梁军,宋妍烨,仇小强*.壮族孕妇血红蛋白浓度和低出生体重关联强度剂量反应关系[J].现代预防医学,2019,46(08):1400-1403+1433.

[34] 韦良家,刘顺,黄东萍,郭雪峰,王娜,盛勇红,莫美乐,梁军,宋妍烨,仇小强*.孕妇血红蛋白浓度与早产关联强度剂量反应关系[J].中华流行病学杂志,2019(04):471-474

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[41] 陈洁华,郭雪峰,刘顺,龙静铧,张国强,黄美辰,仇小强*.广西壮族孕妇血红蛋白水平变化及其对新生儿体重影响的分析[J].中华流行病学杂志, 2017,38(2):154-157

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